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Displaying record number 1843

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Notes

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• Fab 3663: Bivalent Fab 3663 (bF-3663) does not neutralize HXB2 on its own, but it reduces the neutralization IC50 of N36Mut(e,g) peptide, which is a class 3 inhibitor that disrupts trimerization of the N-heptad repeat (N-HR) in the prehairpin intermediate by sequestering the N-HR into N-HR/N36Mut(e,g) heterodimers. Gustchina2008 (neutralization, kinetics)
• Fab 3663: Fab 3663 was selected from a human phage library by panning against a chimeric construct that exposes coiled-coil of gp41 N helices. The epitope for the Fab 3663 consists of: W571, K574 and Q575 with a likely contribution from Q567, and is located in the shallow groove on the N helices, exposed between two C helices in the fusiogenic six-helix bundle conformation of gp41. Fab 3663 had no neutralizing activity. Gustchina2007 (antibody binding site, neutralization, binding affinity)

References

Showing 2 of 2 references.

Gustchina2007 Elena Gustchina, John M. Louis, Son N. Lam, Carole A. Bewley, and G. Marius Clore. A Monoclonal Fab Derived from a Human Nonimmune Phage Library Reveals a New Epitope on gp41 and Neutralizes Diverse Human Immunodeficiency Virus Type 1 Strains. J. Virol., 81(23):12946-12953, Dec 2007. PubMed ID: 17898046. Show all entries for this paper.

Gustchina2008 Elena Gustchina, Carole A. Bewley, and G. Marius Clore. Sequestering of the Prehairpin Intermediate of gp41 by Peptide N36Mut(e,g) Potentiates the Human Immunodeficiency Virus Type 1 Neutralizing Activity of Monoclonal Antibodies Directed against the N-Terminal Helical Repeat of gp41. J. Virol., 82(20):10032-10041, Oct 2008. PubMed ID: 18667502. Show all entries for this paper.