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Displaying record number 166

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MAb ID F11.2.32
HXB2 Location Pol(92-102)
DNA(2358..2390)
Pol Epitope Map
Author Location Protease(36-46 BH10)
Epitope MSLPGRWKPKM Epitope Alignment
MSLPGRWKPKM epitope logo
Ab Type flap region
Neutralizing  
Species (Isotype) mouse(IgG1κ)
Patient  
Immunogen vaccine
Keywords drug resistance, review, structure

Vaccine Details

Vaccine type protein
Vaccine strain B clade BH10
Vaccine component Protease

Notes

Showing 4 of 4 notes.

References

Showing 5 of 5 references.

Lescar1996 J. Lescar, R. Stouracova, M. M. Riottot, V. Chitarra, J. Brynda, M. Fabry, M. Horejsi, J. Sedlacek, and G. A. Bentley. Preliminary crystallographic studies of an anti-HIV-1 protease antibody which inhibits enzyme activity. Protein Sci., 5:966-968, 1996. PubMed ID: 8732768. Show all entries for this paper.

Lescar1997 J. Lescar, R. Stouracova, M. M. Riottot, V. Chitarra, J. Brynda, M. Fabry, M. Horejsi, J. Sedlacek, and G. A. Bentley. Three-Dimensional Structure of an Fab-Peptide Complex: Structural Basis of HIV-1 Protease Inhibition by a Monoclonal Antibody. J. Mol. Biol., 267:1207-1222, 1997. (Genbank: U62632 U62633) F11.2.32 is a MAb raised against HIV-1 protease which inhibits proteolytic activity. The structure of the complex of the Fab fragment and the synthetic peptide that it binds to, residues 36 to 46 of protease, have been determined at 2.2 AA resolution, and that of the Fab in the free state has been determined at 2.6 AA resolution. The conformation of the bound peptide shows no overall structural similarity to the corresponding segment in HIV-1 protease. PubMed ID: 9150407. Show all entries for this paper.

Lescar1999 J. Lescar, J. Brynda, P. Rezacova, R. Stouracova, M. M. Riottot, V. Chitarra, M. Fabry, M. Horejsi, J. Sedlacek, and G. A. Bentley. Inhibition of the HIV-1 and HIV-2 Proteases by a Monoclonal Antibody. Protein Sci., 8:2686-2696, 1999. PubMed ID: 10631984. Show all entries for this paper.

Rezacova2002 P. Rezacova, J. Brynda, M. Fabry, M. Horejsi, R. Stouracova, J. Lescar, V. Chitarra, M. M. Riottot, J. Sedlacek, and G. A. Bentley. Inhibition of HIV Protease by Monoclonal Antibodies. J. Mol. Recognit., 15(5):272-276, Sep-Oct 2002. PubMed ID: 12447903. Show all entries for this paper.

Bartonova2008 Vanda Bartoňová, Vlastimil Král, Irena Sieglová, Jiří Brynda, Milan Fábry, Magdalena Hořejší, Milan Kožíšek, Klára Grantz Šašková, Jan Konvalinka, Juraj Sedláček, and Pavlina Řezáčová. Potent Inhibition of Drug-Resistant HIV Protease Variants by Monoclonal Antibodies. Antiviral Res., 78(3):275-277, Jun 2008. PubMed ID: 18329737. Show all entries for this paper.


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