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Displaying record number 16

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MAb ID	12H-D3b3
HXB2 Location	Gag(62-78) DNA(973..1023)	Gag Epitope Map
Author Location	p17(62-78)
Epitope	`GQLQPSLQTGSEELRSL`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	rat(IgG2a)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	HIV infected-cell lysate
Vaccine strain	B clade IIIB
Vaccine component	HIV-1

Notes

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12H-D3b3: Did not bind live infected cells, only cells that had been made permeable with acetone. Shang1991

References

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Shang1991 F. Shang, H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells. J. Virol., 65:4798-4804, 1991. Six MAbs with linear epitopes were mapped. These Abs could only bind to HIV-infected cells that had been permeablized with acetone. Only G11g1 and G11h3, two antibodies that did not bind to peptides, but only to intact p17, could react with live HIV-1 infected cells. These antibodies were not neutralizing. PubMed ID: 1714518. Show all entries for this paper.