Search Antibody Database

Found 1 matching record:

Displaying record number 1592

Download this epitope record as JSON.

MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Subtype	C, G
Ab Type
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Country	Zambia
Keywords	escape, neutralization

Notes

Showing 1 of 1 note.

Resistance to NAb in plasma from resistant donor-sensitive recipient pairs was correlated with sequence divergence in the gp120 V1-V4 region and to acquisition of length in the gp120 hypervariable domains in donor plasma. Association between nine amino acid positions in V1-V4 and Ab resistance was found, where five of the positions were located in the alpha-2 helix of the gp120 outer domain. These same 5 positions were found to be under positive selection pressure in subtype C sequences from Los Alamos Sequence Database. However, exchange of the alpha-2 helix between resistant donor and sensitive recipient Envs did not alter NAb phenotype, suggesting that positions within alpha-2 helix must be linked to other domains of Env to utilize NAb escape. Rong2007 (neutralization, escape)

References

Showing 1 of 1 reference.

Rong2007 Rong Rong, S. Gnanakaran, Julie M. Decker, Frederic Bibollet-Ruche, Jesse Taylor, Jeffrey N. Sfakianos, John L. Mokili, Mark Muldoon, Joseph Mulenga, Susan Allen, Beatrice H. Hahn, George M. Shaw, Jerry L. Blackwell, Bette T. Korber, Eric Hunter, and Cynthia A. Derdeyn. Unique Mutational Patterns in the Envelope alpha 2 Amphipathic Helix and Acquisition of Length in gp120 Hypervariable Domains Are Associated with Resistance to Autologous Neutralization of Subtype C Human Immunodeficiency Virus Type 1. J. Virol., 81(11):5658-5668, Jun 2007. PubMed ID: 17360739. Show all entries for this paper.