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Displaying record number 1588

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp41
Epitope
Ab Type
Neutralizing
Species (Isotype)	mouse, rabbit
Patient
Immunogen	vaccine
Keywords	neutralization, vaccine antigen design

Vaccine Details

Vaccine type	DNA prime with protein boost
Vaccine component	other
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 1 of 1 note.

High levels of gp120-specific Abs were elicited when mice and rabbits were immunized by DNA priming and protein boosting with G1 and G2 grafts, consisting of 2F5 and 4E10, and 4E10 epitopes, respectively, engrafted into the V1/V2 region of gp120. A consistent NAb response against the homologous JR-FL virus was detected in rabbits but not in mice. 4E10 bound to the engrafted construct, but embedding the MPER epitopes in the immunogenic V1/V2 region did not result in eliciting anti-MPER antibodies in mice or rabbits. Law2007 (neutralization, vaccine antigen design)

References

Showing 1 of 1 reference.

Law2007 Mansun Law, Rosa M. F. Cardoso, Ian A. Wilson, and Dennis R. Burton. Antigenic and Immunogenic Study of Membrane-Proximal External Region-Grafted gp120 Antigens by a DNA Prime-Protein Boost Immunization Strategy. J. Virol., 81(8):4272-4285, Apr 2007. PubMed ID: 17267498. Show all entries for this paper.