Search Antibody Database

Found 1 matching record:

Displaying record number 1579

Download this epitope record as JSON.

MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp140
Epitope
Subtype	A, B, C, M group
Ab Type
Neutralizing	P
Species (Isotype)	guinea pig
Patient
Immunogen	vaccine
Keywords	antibody binding site, neutralization, subtype comparisons, vaccine antigen design, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade JRFL, other, B clade BaL, A clade 92RW020, C clade 97ZA012, M group consensus
Vaccine component	gp120, gp140ΔCFI, other
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 1 of 1 note.

A group M consensus envelope gene (CON-S) was designed that was central to the M group and a consensus of the consensus sequences of the major clades. The gp140δCFI protein of this virus and gp140CFI and gp140CF proteins of CON6 and other WT viruses were expressed in recombinant vaccinia viruses. The CON-S was shown to induce cross-subtype neutralizing Abs in immunized guinea pigs with greater breadth (neutralizing most A, B and C clade isolates) and titer than the WT proteins. Much of the neutralizing activity induced by CON-S Env was absorbed by the CON-S V3 peptide. Liao2006 (antibody binding site, neutralization, vaccine antigen design, variant cross-reactivity, subtype comparisons)

References

Showing 1 of 1 reference.

Liao2006 Hua-Xin Liao, Laura L. Sutherland, Shi-Mao Xia, Mary E. Brock, Richard M. Scearce, Stacie Vanleeuwen, S. Munir Alam, Mildred McAdams, Eric A. Weaver, Zenaido Camacho, Ben-Jiang Ma, Yingying Li, Julie M. Decker, Gary J. Nabel, David C. Montefiori, Beatrice H. Hahn, Bette T. Korber, Feng Gao, and Barton F. Haynes. A Group M Consensus Envelope Glycoprotein Induces Antibodies That Neutralize Subsets of Subtype B and C HIV-1 Primary Viruses. Virology, 353(2):268-282, 30 Sep 2006. PubMed ID: 17039602. Show all entries for this paper.