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Displaying record number 1574

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MAb ID	polyclonal
HXB2 Location	Gag	Gag Epitope Map
Author Location	Gag
Epitope
Ab Type
Neutralizing
Species (Isotype)	mouse(IgA, IgG)
Patient
Immunogen	vaccine
Keywords	genital and mucosal immunity

Vaccine Details

Vaccine type	DNA prime with vaccinia boost
Vaccine strain	other
Vaccine component	Gag

Notes

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BALB/c mice were immunized with DNA plasmid and PEI/DNA complexes and boosted with recombinant TianTan vaccinia virus (rTTV) expressing HIV-1 Gag. PEI is polyethylenimine, a polymer with the high cationic charge density. HIV-specific IgG Abs in sera were comparable between DNA and PEI/DNA immunized mice. However, PEI/DNA stimulated significantly higher IgA responses than DNA alone in different mucosal secretions, both with or without rTTV boosting. Intramuscular rTTV boosting enhanced Ab immune responses raised by intranasal priming. Huang2007a (genital and mucosal immunity)

References

Showing 1 of 1 reference.

Huang2007a Xianggang Huang, Jianqing Xu, Chao Qiu, Li Ren, Lianxing Liu, Yanmin Wan, Ning Zhang, Hong Peng, and Yiming Shao. Mucosal Priming with PEI/DNA Complex and Systemic Boosting with Recombinant TianTan Vaccinia Stimulate Vigorous Mucosal and Systemic Immune Responses. Vaccine, 25(14):2620-2629, 30 Mar 2007. PubMed ID: 17280743. Show all entries for this paper.