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MAb ID
HXB2 Location	HIV-1	HIV-1 Epitope Map
Author Location
Epitope
Ab Type
Neutralizing
Species (Isotype)	human
Patient
Immunogen
Keywords	escape

Notes

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The greatest amino acid diversity is found in sites in the HIV genome that are spanned by antibody epitopes. Sites spanned by CTL epitopes, not but not by antibody epitopes, showed reduced amino acid diversity even in comparison to non-epitope sites. However, mutations within CTL epitopes were more likely to be convergent than mutations within antibody epitopes. These patterns were consistent both in Gag and Env. Piontkivska2006 (escape)

References

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Piontkivska2006 Helen Piontkivska and Austin L. Hughes. Patterns of Sequence Evolution at Epitopes for Host Antibodies and Cytotoxic T-Lymphocytes in Human Immunodeficiency Virus Type 1. Virus Res., 116(1-2):98-105, Mar 2006. PubMed ID: 16214253. Show all entries for this paper.