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Displaying record number 1540

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	rabbit
Patient
Immunogen	vaccine
Keywords	antibody binding site, vaccine antigen design, vaccine-induced immune responses

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade ADA
Vaccine component	Env fragments in a pre-fusion state trimer
Adjuvant	Complete Freund's Adjuvant (CFA), Incomplete Freund's Adjuvant (IFA)

Notes

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A gp140 prefusion state trimer composed of gp41 truncated at Lys665, and gp120 C1 and C5 (topless gp140), was engineered and used to immunize rabbits. No NAbs were raised, although the polyclonal sera recognized many regions of the truncated Env. Qiao2005 (antibody binding site, vaccine antigen design, vaccine-induced immune responses)

References

Showing 1 of 1 reference.

Qiao2005 Zhi-Song Qiao, Mikyung Kim, Bruce Reinhold, David Montefiori, Jia-huai Wang, and Ellis L. Reinherz. Design, Expression, and Immunogenicity of a Soluble HIV Trimeric Envelope Fragment Adopting a Prefusion gp41 Configuration. J. Biol. Chem., 280(24):23138-23146, 17 Jun 2005. PubMed ID: 15833740. Show all entries for this paper.