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Displaying record number 1538

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	co-receptor, vaccine antigen design

Vaccine Details

Vaccine type	fixed fusion-intermediate
Vaccine strain	B clade US005.11, FASH isolate
Vaccine component	Env

Notes

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HIV-1 fusion complexes were prepared from cell lines expressing R5 HIV-1 gp120/gp41 and CD4-CCR5. Fusion complexes were prepared at different temperatures (21, 30 or 37 degrees C) with different fixative combinations, and used to immunize mice. Complexes prepared at 37 degrees were the most immunogenic, suggesting that fixation of multiple conformation intermediates may be helpful. Neutralizing Abs were raised against both R5 (strain BaL) and X4 (strain 213) viruses. Zipeto2005 (co-receptor, vaccine antigen design)

References

Showing 1 of 1 reference.

Zipeto2005 Donato Zipeto, Andrea Matucci, Chiara Ripamonti, Gabriella Scarlatti, Paola Rossolillo, Marco Turci, Silvia Sartoris, Giuseppe Tridente, and Umberto Bertazzoni. Induction of Human Immunodeficiency Virus Neutralizing Antibodies Using Fusion Complexes. Microbes Infect., 2005. PubMed ID: 16039896. Show all entries for this paper.