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Displaying record number 1498

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MAb ID	polyclonal
HXB2 Location	gp160(662-667) DNA(8208..8225)	gp160 Epitope Map
Author Location	gp41
Epitope	`ELDKWA`	Epitope Alignment
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	vaccine antigen design, vaccine-induced immune responses

Vaccine Details

Vaccine type	peptide
Vaccine component	gp41
Adjuvant	Complete Freund's Adjuvant (CFA), Incomplete Freund's Adjuvant (IFA)

Notes

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A peptide containing eight copies of the MAb 2F5's ELDKWA-epitope separated by aa spacers GSGGGGS, RS, and GS was used to test the impact of spacers on eliciting antibody responses to peptides. Both GSGGGGS and GS induced high titers of ELDKWA peptide-specific Abs in BALB/c mice, which reacted with rsgp41. Liu2005a (vaccine antigen design, vaccine-induced immune responses)

References

Showing 1 of 1 reference.

Liu2005a Zuqiang Liu, Zuguang Wang, and Ying-Hua Chen. Predefined Spacers between Epitopes on a Recombinant Epitope-Peptide Impacted Epitope-Specific Antibody Response. Immunol. Lett., 97(1):41-45, 15 Feb 2005. PubMed ID: 15626474. Show all entries for this paper.