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Displaying record number 148

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MAb ID	AD2
HXB2 Location	Gag(441-449) DNA(2110..2136)	Gag Epitope Map
Author Location	p7(64-72)
Epitope	`YKGRPGNFL`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine component	p7 Gag

Notes

Showing 2 of 2 notes.

AD2: Similarity level of the AD2 binding site pentapeptide YKGRP to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 4 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
AD2: Binds at C term of NCp7. Tanchou1995

References

Showing 2 of 2 references.

Tanchou1995 V. Tanchou, T. Delaunay, M. Bodeus, B. Roques, J. L. Darlix, and R. Benarous. Conformational Changes between Human Immunodeficiency Virus Type 1 Nucleocapsid Protein NCp7 and its Precursor NCp15 as Detected by Anti-NCp7 Monoclonal Antibodies. J. Gen. Virol., 76:2457-2466, 1995. PubMed ID: 7595349. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.