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Displaying record number 1454

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords	adjuvant comparison

Vaccine Details

Vaccine type	protein
Vaccine component	gp120
Adjuvant	C3d fusion, Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 1 of 1 note.

Fusion of C3d repeats and the addition of Ribi adjuvant to gp120 variant glycoprotein (gp120δC1/C5(C3d)2 enhanced gp120-specific Ab responses, but Ribi alone gave almost comparable enhancement. Thus C3d as an adjuvant may be of particular value when used alone in conditions where avoiding denaturation and preservation of the native structure is important. Koch2005 (adjuvant comparison)

References

Showing 1 of 1 reference.

Koch2005 Markus Koch, James Frazier, Joseph Sodroski, and Richard Wyatt. Characterization of Antibody Responses to Purified HIV-1 gp120 Glycoproteins Fused with the Molecular Adjuvant C3d. Virology, 340(2):277-284, 30 Sep 2005. PubMed ID: 16051303. Show all entries for this paper.