Search Antibody Database

Found 1 matching record:

Displaying record number 1420

Download this epitope record as JSON.

MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Subtype	A, B, C
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	P
Species (Isotype)	guinea pig
Patient
Immunogen	vaccine
Keywords	vaccine antigen design, vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type	DNA, adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	gp140ΔCFI

Notes

Showing 1 of 1 note.

Guinea pigs were immunized with a hybrid HXB2/BaL Env (HIV HXB/BaL gp140δCFI, clade B) in which the tip of the V3 loop (GPGRA) was replaced with the 2F5 epitope LELDKWAS. 2F5 bound to the Env that carried the V3-replacement 2F5 epitope, but antibodies against this construct only neutralized the X4-tropic lab adapted HIV strain IIIB, and not CCR5-HIV BaL or SF162 isolates. This immunogen, a single B clade immunogen, and a mixture of A + B + C clade envelopes, were compared. The single B clade immunogen had neutralizing activity against some B clade viruses. The A+B+C mixture was found to maintain the B clade responses, while eliciting NAbs with greater breadth when tested against a panel 19 A, B and C clade primary isolates. Chakrabarti2005 (vaccine antigen design, variant cross-reactivity, vaccine-induced immune responses)

References

Showing 1 of 1 reference.

Chakrabarti2005 Bimal K. Chakrabarti, Xu Ling, Zhi-Yong Yang, David C. Montefiori, Amos Panet, Wing-Pui Kong, Brent Welcher, Mark K. Louder, John R. Mascola, and Gary J. Nabel. Expanded Breadth of Virus Neutralization after Immunization with a Multiclade Envelope HIV Vaccine Candidate. Vaccine, 23(26):3434-3445, 16 May 2005. PubMed ID: 15837367. Show all entries for this paper.