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Displaying record number 1419

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	CRF02_AG
Ab Type
Neutralizing
Species (Isotype)	macaque(IgG)
Patient
Immunogen	vaccine
Keywords	vaccine antigen design, vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type	virus-like particle (VLP), DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain	CRF02 IC0928
Vaccine component	Env, Gag, Pol

Notes

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Macaques were given a Gag-Pol-Env DNA prime followed by a MVA boost, comparing two DNA constructs, one that resulted mature VLPs with processed Gag (IC48) and one that had a point mutation in Gag that resulted in immature VLPs (IC1-90). Both vaccines gave antibody and T-cell responses to Env and Gag, although negligible neutralizing antibody responses were found. Autologous virus is difficult to neutralize, but the antibodies in the vaccinated macaques also did not neutralize the laboratory adapted B clade MN strain. Ellenberger2005 (vaccine antigen design, variant cross-reactivity, vaccine-induced immune responses)

References

Showing 1 of 1 reference.

Ellenberger2005 Dennis Ellenberger, Linda Wyatt, Bin Li, Suzan Buge, Nattawan Lanier, I. Vanesssa Rodriguez, Carlos A. Sariol, Melween Martinez, Michael Monsour, Jennifer Vogt, James Smith, Ronald Otten, David Montefiori, Edmundo Kraiselburd, Bernard Moss, Harriet Robinson, Janet McNicholl, and Salvatore Butera. Comparative Immunogenicity in Rhesus Monkeys of Multi-Protein HIV-1 (CRF02\_AG) DNA/MVA Vaccines Expressing Mature and Immature VLPs. Virology, 340(1):21-32, 15 Sep 2005. PubMed ID: 16023165. Show all entries for this paper.