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Displaying record number 1417

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Subtype	multiple
Ab Type	gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	rabbit
Patient
Immunogen	vaccine
Keywords	vaccine antigen design, variant cross-reactivity

Vaccine Details

Vaccine type	peptide
Vaccine strain	natural variants
Vaccine component	gp140

Notes

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2F5 recognizes the epitope ELDKWA, but does not neutralize viruses carrying the commonly found mutated epitope variants: ELDeWA, ELDsWA, ELDnWA, ELDqWA, ELDtWA, or ELnKWA. Peptide cocktails containing ELDKWA, ELnKWA, ELDeWA, and ELeKWA elicit polyclonal antibodies in rabbits that can bind to all of the natural variants that are escape variants for 2F5 expressed in gp41 via WB, as well as ELDrWA. Dong2005 (vaccine antigen design, variant cross-reactivity)

References

Showing 1 of 1 reference.

Dong2005 Xiao-Nan Dong, Yi Wu, and Ying-Hua Chen. The Neutralizing Epitope ELDKWA on HIV-1 gp41: Genetic Variability and Antigenicity. Immunol. Lett., 101(1):81-86, 15 Oct 2005. PubMed ID: 15951025. Show all entries for this paper.