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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120( SF2)
Epitope
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	baboon, human
Patient
Immunogen	HIV-1 infection, vaccine
Keywords	adjuvant comparison, vaccine antigen design, vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF2
Vaccine component	gp120
Adjuvant	aluminum hydroxide, Incomplete Freund's Adjuvant (IFA), muramyl-dipeptide base adjuvant (Syntex)

Notes

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Immunization with native glycosylated rgp120SF2 produced Abs directed against linear and conformational epitopes. Denatured, deglycosylated env2-3 (SF2) produced Abs against only linear determinants. Sera from 8/8 rgp120SF2 vs 3/8 env2-3SF2 immunized baboons cross-neutralized HIV-MN. Only 5/8 rgp120SF2 vaccinated animals had neutralizing activity against HIV-HTLV-IIIB and HIV-BRU. Abs from infected people who reacted with rgp120SF2 showed broad cross-neutralization of HIV-1MN, HIV- BRU, HIV-Zr6 and HIV-SF2 isolates, in comparison to env2-3(SF2)immunization, which only neutralized HIV-1 MN. Stronger neutralization potency of Ab responses was observed in baboons using Alum and MF101 as adjuvants. Steimer1991 (adjuvant comparison, vaccine antigen design, variant cross-reactivity, vaccine-induced immune responses)

References

Showing 1 of 1 reference.

Steimer1991 K. S. Steimer and N. L. Haigwood. Importance of Conformation on the Neutralizing Antibody Response to HIV-1 gp120. Biotechnol. Ther., 2(1-2):63-89, 1991. PubMed ID: 1726963. Show all entries for this paper.