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Displaying record number 1381

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp140( SF162)
Epitope
Subtype	B
Ab Type	gp120 C5, gp120 C1-C2, gp120 CD4BS, gp120 V3 // V3 glycan (V3g), gp120 V1-V2
Neutralizing
Species (Isotype)	macaque
Patient
Immunogen	vaccine
Keywords	vaccine antigen design, vaccine-induced immune responses

Vaccine Details

Vaccine type	DNA prime with protein boost
Vaccine strain	B clade SF162
Vaccine component	gp140, gp140ΔV2

Notes

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Vaccination of macaques with SF162gp140 was compared with vaccination with SF162 deltaV2gp140. V1, V2, V3, CD4BS, C1 and C2 antibodies were elicited by the intact SF612, and the antibodies were able to neutralize some heterologous strains. Deletion of the V2 loop altered the response so that there was a higher ratio of CD4BS antibody made relative to V3 antibody, but did not increase overall amount of CD4BS antibodies. Antibodies against C5 were also elicited by the deltaV2 construct. Overall, the deltaV2 construct was better able to raise antibodies that could cross-neutralize heterologous strains. Using a cleaved versus fused form of gp120 altered the ratio of C1 to C5 antibodies raised, with more C5 response to the fused form. Srivastava2003 (vaccine antigen design, vaccine-induced immune responses)

References

Showing 1 of 1 reference.

Srivastava2003 Indresh K. Srivastava, Keating VanDorsten, Lucia Vojtech, Susan W. Barnett, and Leonidas Stamatatos. Changes in the Immunogenic Properties of Soluble gp140 Human Immunodeficiency Virus Envelope Constructs upon Partial Deletion of the Second Hypervariable Region. J. Virol., 77(4):231023-20, Feb 2003. PubMed ID: 12551968. Show all entries for this paper.