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Displaying record number 1371

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120 (V3)
Epitope
Subtype	A
Ab Type
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	variant cross-reactivity

Vaccine Details

Vaccine type	hepatitis B surface antigen lipoprotein particles (HsBAg)
Vaccine strain	A clade
Vaccine component	CD4BS, Env V3
Adjuvant	Complete Freund's Adjuvant (CFA), Incomplete Freund's Adjuvant (IFA)

Notes

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Vaccinations with either the subtype A V3 consensus in a Hepatitis B carrier protein, or a multiple antigen peptide (MAP) construct (mixotope) carrying some 5000 V3s representing the diversity of subtype A V3 loops, were compared. Each was combined with a C4 peptide spanning a region involved in CD4 binding. BALB/c mice were used for immunization. The consensus V3 gave higher and more cross-reactive responses than the mixotope. The mixotope response was restricted to the most conserved region of V3, while the consensus antibodies tended to recognize heptamers representing both sides and the tip of the loop. Antibodies against the C4 region were also raised. Cruz2004 (variant cross-reactivity)

References

Showing 1 of 1 reference.

Cruz2004 Luis J. Cruz, Enrique Iglesias, Julio C. Aguilar, Luis J. González, Osvaldo Reyes, Fernando Albericio, and David Andreu. A Comparative Study of Different Presentation Strategies for an HIV Peptide Immunogen. Bioconjug. Chem., 15(1):112-120, Jan-Feb 2004. PubMed ID: 14733590. Show all entries for this paper.