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Displaying record number 1369

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type
Neutralizing
Species (Isotype)	chimpanzee, human
Patient
Immunogen	vaccine
Keywords	variant cross-reactivity

Vaccine Details

Vaccine strain	B clade IIIB
Vaccine component	gp120, gp160
Adjuvant	aluminum hydroxide

Notes

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Antisera derived from human or chimpanzee immunized with IIIB-rgp120 showed broad cross-reactivity to HIV-1 isolates MN, IIIB, JRcsf and NY-5 (subtype B), Z6 (subtype D), A244 (subtype E)and Z321 (subtype A). Sera of IIIB-rgp120 chimpanzees cross-reacted with 6/8 V3 peptides derived from HIV-1 isolates (MN, NY5, SF2, RF, CDC4 and IIIB). Human sera only recognized 1/8 V3 peptides, HIV-1 MN. The magnitude, duration, avidity and half-life of IIIB-rgp120-specific Ab-responses were species specific. Sera derived from IIIB-rgp120-immunized humans and chimpanzees inhibited binding of both IIIB- and MN-derived rgp120 to cell-surface CD4. Berman1994 (variant cross-reactivity)

References

Showing 1 of 1 reference.

Berman1994 P. W. Berman, D. J. Eastman, D. M. Wilkes, G. R. Nakamura, T. J. Gregory, D. Schwartz, G. Gorse, R. Belshe, M. L. Clements, and R. A. Byrn. Comparison of the Immune Response to Recombinant gp120 in Humans and Chimpanzees. AIDS, 8(5):591-601, May 1994. PubMed ID: 7520248. Show all entries for this paper.