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Displaying record number 1367

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Ab Type
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection, vaccine
Keywords	review, vaccine antigen design

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This review summarizes neutralizing epitopes on Env and their use as vaccine antigens. Most antibodies are not neutralizing, and while some antibodies directed to conserved domains can neutralize the virus, these are generally poorly immunogenic. Variable loops do not elicit much cross-reactive neutralization, although the stem regions of these loops are more conserved so may have some promise. Polyclonal pooled sera from infected people can generally neutralize heterologous virus, suggesting that neutralizing epitopes are yet to be discovered. Polyvalent vaccine design is considered key. Zolla-Pazner2004 (vaccine antigen design, review)

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Zolla-Pazner2004 Susan Zolla-Pazner. Identifying Epitopes of HIV-1 that Induce Protective Antibodies. Nat. Rev. Immunol., 4(3):199-210, Mar 2004. PubMed ID: 15039757. Show all entries for this paper.