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MAb ID	polyclonal
HXB2 Location	gp160(579-599) DNA(7959..8021)	gp160 Epitope Map
Author Location	gp41(586-606)
Epitope	`RILAVERYLKDQQLLGIWGCS`	Epitope Alignment
Epitope Name	SM284 peptide
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Keywords	assay or method development

Notes

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Immunoabsorbant peptide antigen RIAVERYLKDQQLLGIWGCS was used in a solid-phase enzyme immunoassay (EIA) to detect gp41-specific Abs in sera of virtually all HIV-1 infected individuals tested, with no false positives. This one 21-amino acid-long peptide is recognized by sera from almost all AIDS patients; it can be easily synthesized and employed for serological testing for HIV infection. Wang1986 (assay or method development)

References

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Wang1986 James J. G. Wang, Samuel Steel, Rosanne Wisniewolski, and Chang Yi Wang. Detection of Antibodies to Human T-Lymphotropic Virus Type III by Using a Synthetic Peptide of 21 Amino Acid Residues Corresponding to a Highly Antigenic Segment of gp41 Envelope Protein. Proc. Natl. Acad. Sci. U.S.A., 83(16):6159-6163, Aug 1986. PubMed ID: 2426711. Show all entries for this paper.