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Displaying record number 1291

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MAb ID	10D8
HXB2 Location	Env	Env Epitope Map
Author Location	gp160 (V3)(303-338)
Epitope
Subtype	B
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human
Patient
Immunogen
Keywords

Notes

Showing 1 of 1 note.

10D8: Polyanionic polysaccharides were proposed to inhibit viral functions such as binding and syncytia formation through interactions mediated through the local high positive charge density in the V3 loop. The binding of this anti-V3 antibody is inhibited by dextransulfate. Callahan1991

References

Showing 1 of 1 reference.

Callahan1991 Lawrence N. Callahan, Michael Phelan, Margherita Mallinson, and Michael A. Norcross. Dextran Sulfate Blocks Antibody Binding to the Principal Neutralizing Domain of Human Immunodeficiency Virus Type 1 without Interfering with gp120-CD4 Interactions. J. Virol., 65(3):1543-1550, Mar 1991. PubMed ID: 1995952. Show all entries for this paper.