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Displaying record number 1289

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	Env( YU-2)
Epitope
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords	adjuvant comparison, vaccine antigen design

Vaccine Details

Vaccine type	DNA with CMV promotor, DNA prime with protein boost
Vaccine strain	B clade YU2
Vaccine component	gp140
Adjuvant	monophosphoryl lipid A, trehalose dicorynomycolate

Notes

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DNA vaccines encoding an uncleaved form of YU-2 gp140 stabilized with a synthetic trimerization domain isolated from the fibritin (FT) protein of the T4 bacteriophage and fused to murine C3d as a molecular adjuvant, could induce low titers of neutralizing antibodies against primary isolates HIV-1 YU-2 and HIV-1 ADA. DNA was administered by gene gun immunization to BALB/c mice, protein boost was performed by intraperitoneal injection. C3d is a component of the innate immune system that can serve as a molecular adjuvant and had been previously shown to enhance immunogenicity. Bower2004 (adjuvant comparison, vaccine antigen design)

References

Showing 1 of 1 reference.

Bower2004 Joseph F. Bower, Xinzhen Yang, Joseph Sodroski, and Ted M. Ross. Elicitation of Neutralizing Antibodies with DNA Vaccines Expressing Soluble Stabilized Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers Conjugated to C3d. J. Virol., 78(9):4710-4719, May 2004. PubMed ID: 15078953. Show all entries for this paper.