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Displaying record number 1270

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MAb ID	Ia7
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Keywords	antibody interactions

Notes

Showing 2 of 2 notes.

Ia7 database note: This antibody is distinct from IA7 described by Gao2014.
Ia7: scFv 4KG5 reacts with a conformational epitope that is formed by the V1V2 and V3 loops and the bridging sheet (C4) region of gp120 and is influenced by carbohydrates. Of a panel of MAbs tested, only NAb b12 enhanced 4KG5 binding to gp120 JRFL. MAbs to the following regions diminished 4KG5 binding: V2 loop, V3 loop, V3-C4 region, CD4BS. MAbs directed against C1, CD4i, C5 regions didn't impact 4KG5 binding. These results suggest that the orientation or dynamics of the V1/V2 and V3 loops restricts CD4BS access on the envelope spike, and IgG1b12 can uniquely remain unaffected by these loops. This is a novel CD4BS Fab first used in this study. Zwick2003a (antibody interactions)

References

Showing 1 of 1 references.

Zwick2003a Michael B. Zwick, Robert Kelleher, Richard Jensen, Aran F. Labrijn, Meng Wang, Gerald V. Quinnan, Jr., Paul W. H. I. Parren, and Dennis R. Burton. A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1, V2, and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunoglobulin G1 b12. J. Virol., 77(12):6965-6978, Jun 2003. PubMed ID: 12768015. Show all entries for this paper.