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Displaying record number 1262

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MAb ID	polyclonal
HXB2 Location	gp160(659-670) DNA(8199..8234)	gp160 Epitope Map
Author Location	gp41(659-670)
Epitope	ELLELDKWASLW	Epitope Alignment
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	guinea pig
Patient
Immunogen	vaccine
Keywords	antibody binding site, binding affinity, vaccine antigen design

Vaccine Details

Notes

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• 2F5: Cyclic peptides ELLELDKWASLW that adopt constrained beta-turn conformation of the 2F5 epitope beta-turn in the complexed crystal structure were synthesized and optimize 2F5 binding affinity. This peptide elicits high titer peptide-specific immune responses in guinea pigs that do not neutralize; the authors propose this may be the result of a short CDR3 loop in guinea pigs and additional recessed contact points between 2F5 and gp41. McGaughey2003 (antibody binding site, vaccine antigen design, binding affinity)

References

Showing 1 of 1 reference.

McGaughey2003 G. B. McGaughey, M. Citron, R. C. Danzeisen, R. M. Freidinger, V. M. Garsky, W. M. Hurni, J. G. Joyce, X. Liang, M. Miller, J. Shiver, and M. J. Bogusky. HIV-1 Vaccine Development: Constrained Peptide Immunogens Show Improved Binding to the Anti-HIV-1 gp41 MAb. Biochemistry, 42(11):3214-3223, 25 Mar 2003. PubMed ID: 12641452. Show all entries for this paper.