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Displaying record number 1260

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp41
Epitope
Subtype	B
Ab Type	gp41
Neutralizing
Species (Isotype)	rabbit(IgG)
Patient
Immunogen	vaccine
Keywords	vaccine antigen design

Vaccine Details

Vaccine type	peptide
Vaccine component	gp41

Notes

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Polyclonal Abs raised against soluble trivalently linked N35CCG-N13 and N34CCG, the internal trimeric core of the coiled-coil ectodomain, inhibit HIV-1 Env-mediated cell fusion at levels comparable to 2G12. Louis2003 (vaccine antigen design)

References

Showing 1 of 1 reference.

Louis2003 John M. Louis, Issa Nesheiwat, LengChee Chang, G. Marius Clore, and Carole A. Bewley. Covalent Trimers of the Internal N-Terminal Trimeric Coiled-Coil of gp41 and Antibodies Directed against Them Are Potent Inhibitors of HIV Envelope-Mediated Cell Fusion. J. Biol. Chem., 278(22):20278-20285, 30 May 2003. PubMed ID: 12654905. Show all entries for this paper.