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Displaying record number 1252

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	macaque(IgG)
Patient
Immunogen	vaccine
Keywords	adjuvant comparison, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade W61D
Vaccine component	gp120, Nef, Tat
Adjuvant	AS02A, AS06 (CpG, aluminum hydroxide)

Notes

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Monkeys were immunized with different combinations of gp120/NefTat/SIV-Tat three times over a three-month time period and intravenously challenged with SHIV 89.6P four weeks after the last immunization. Vaccination induced anti-Tat, -Nef and -gp120 Ab responses that decreased until challenge. Neutralizing Ab responses against HIV-1 MN and HIV-1 W61D were observed. Vaccination with the combination of all three proteins reduced viral load and kept animals from a CD4+ T cell decline, preventing AIDS for more than 2.5 years. The adjuvant AS02A elicited NAbs and protected from disease, while AS06 did not. gp120 alone or TatNef/SIV-Tat without gp120 could not protect from disease. Voss2003 (adjuvant comparison, variant cross-reactivity)

References

Showing 1 of 1 reference.

Voss2003 Gerald Voss, Kelledy Manson, David Montefiori, David I Watkins, Jonathan Heeney, Michael Wyand, Joe Cohen, and Claudine Bruck. Prevention of Disease Induced by a Partially Heterologous AIDS Virus in Rhesus Monkeys by Using an Adjuvanted Multicomponent Protein Vaccine. J. Virol., 77(2):1049-1058, Jan 2003. PubMed ID: 12502820. Show all entries for this paper.