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Displaying record number 1228

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MAb ID	polyclonal
HXB2 Location	Gag	Gag Epitope Map
Author Location	Gag
Epitope
Ab Type
Neutralizing
Species (Isotype)	macaque
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	DNA, protein, virus-like particle (VLP), PLG microparticle
Adjuvant	E. coli heat labile enterotoxin

Notes

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This study evaluates different vaccine technologies that avoid live vectors including plasmid DNA, recombinant p55Gag protein or gag-pol administered by polylactide coglycolide (PLG) microparticles, LTK63 as adjuvant, VLP, and plasmid DNA. 4/4 macaques primed with Gag-PLG and LTK63 showed strong antibody responses after the fourth immunization at week six. The best CTL responses were found for gag DNA, the best Th and Ab were obtained using Gag protein on PLG microparticles; Gag DNA priming with a PLG-protein boost gave high level CTL, Th and Ab responses. Otten2003

References

Showing 1 of 1 reference.

Otten2003 Gillis Otten, Mary Schaefer, Catherine Greer, Maria Calderon-Cacia, Doris Coit, Jina Kazzaz, Angelica Medina-Selby, Mark Selby, Manmohan Singh, Mildred Ugozzoli, Jan zur Megede, Susan W. Barnett, Derek O'Hagan, John Donnelly, and Jeffrey Ulmer. Induction of Broad and Potent Anti-Human Immunodeficiency Virus Immune Responses in Rhesus Macaques by Priming with a DNA Vaccine and Boosting with Protein-Adsorbed Polylactide Coglycolide Microparticles. J. Virol., 77(10):6087-6092, May 2003. PubMed ID: 12719603. Show all entries for this paper.