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Displaying record number 1218

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MAb ID	E5
HXB2 Location	Nef(170-181) DNA(9304..9339)	Nef Epitope Map
Author Location	Nef(170-181)
Epitope	LHGMDDPEREVL?	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgM)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation

Vaccine Details

Notes

Showing 2 of 2 notes.

• E5: Similarity level of the E5 binding site pentapeptide GMDDP to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 1 time, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
• E5: BALB/c mice were immunized with Nef protein to create a series of anti-Nef antibodies. E5 bound to the peptide spanning amino acids 170-181; we inferred the amino acids from the positions in the NL-43 strain. E5 also bound to the complete Nef protein. Otake1997 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
Otake1997 Kaori Otake, Yoichi Fujii, Masato Tashiro, Akio Adachi, and Junzoh Kitoh. Epitope Mapping of Murine Monoclonal Antibodies against Human Immunodeficiency Virus Type 1 Nef. Exp. Anim., 46(1):53-58, Jan 1997. PubMed ID: 9027472. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.