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Displaying record number 1209

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MAb ID	6E9
HXB2 Location	Pol	Pol Epitope Map
Author Location	RT( BH-10)
Research Contact	Amon Hizi, Sackler School of Medicine, Tel Aviv, Isreal
Epitope
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	human
Patient
Immunogen	in vitro stimulation or selection
Keywords	antibody generation, antibody sequence, immunotherapy

Notes

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6E9: One of five human single chain Fv (ScFv) Abs isolated from an phage display library. F-6 was shown to the carboxyl terminal segment of the p66 RT polypeptide, corresponding to RNase H. F-6 inhibited the DNA and RNA-dependent DNA polymerase (RDDP) activities of HIV-1 RT; two others, 6E9 and 5B11, inhibited RDDP and so have possible therapeutic potential. Herschhorn2003 (antibody generation, immunotherapy, antibody sequence)

References

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Isolation Paper
Herschhorn2003 Alon Herschhorn, Arie Admon, and Amnon Hizi. Recombinant Human Antibodies against the Reverse Transcriptase of Human Immunodeficiency Virus Type-1. Biochim. Biophys. Acta, 1648(1-2):154-163, 30 May 2003. PubMed ID: 12758158. Show all entries for this paper.