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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Research Contact	Rebeca Geffin, Miami School of Medicine
Epitope
Ab Type
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Keywords	autologous responses, escape, rate of progression, responses in children

Notes

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A longitudinal study of NAb responses in perinatally HIV-1 infected infants and children was undertaken, including 7 with rapid progression (RP) and 9 who did not progress rapidly (NRP). A subset of both RPs and NRPs had some plasma samples that could neutralize contemporaneous autologous viral isolates after 6 months of age, but most isolates could not be neutralized by contemporaneous plasma, only by later samples. The non-contemporaneous NAbs would persist for years, had highest titers against earlier isolates, and tended to be more potent in NRP children. This study indicates that there is ongoing NAb escape in HIV-1+ children. No correlation between HIV RNA levels and Ab production was established, although this might have been complicated by treatment. Geffin2003 (autologous responses, escape, responses in children, rate of progression)

References

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Geffin2003 Rebeca Geffin, Cecelia Hutto, Carole Andrew, and Gwendolyn B. Scott. A Longitudinal Assessment of Autologous Neutralizing Antibodies in Children Perinatally Infected with Human Immunodeficiency Virus Type 1. Virology, 310(2):207-215, 5 Jun 2003. PubMed ID: 12781708. Show all entries for this paper.