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Displaying record number 1193

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	B, C, CRF01_AE
Ab Type
Neutralizing
Species (Isotype)	mouse, rabbit(IgG)
Patient
Immunogen	vaccine
Keywords	subtype comparisons, variant cross-reactivity

Vaccine Details

Vaccine type	Venezuelan equine encephalitis virus (VEE)
Vaccine strain	B clade R2
Vaccine component	gp160ΔCT

Notes

Showing 3 of 3 notes.

C3H/He mice immunized with replicons expressing RT env protein or the VEE env vector pGP expressing either gp140 or gp160 showed cross-reactive neutralizing Ab responses to five clade B env proteins, a Chinese clade C strain and weakly against a Chinese clade E (CRF-1) strain. Dong2003
Subcutaneous or intradermal immunization with VEE replicons expressing HIV-1 R2 gp140 and with HIV-1 R2 gp160 lacking the cytoplasmic tail. Sera from 3/3 rabbits inhibited SF162 infectivity and 2/3 rabbits were able to neutralize the R2 strain. Dong2003
Mice and rabbits were immunized with Venezuelan equine encephalitis virus (VEE) replicon system particles expressing HIV-1 Env from the clone R2 that was derived from a virus that was neutralization sensitive and isolated from an individual that made strong NAb responses. Stronger and faster NAb responses were induced with replicons expressing gp160 with the cytoplasmic tail deleted than with gp160 or gp140. NAb responses against heterologous strain SF162 were similar in BALB/c and C3H/He mice and enhanced compared to responses elicited in C57BL/6 mice. Serum from mice neutralized 5 primary clade B env proteins, a Chinese clade C strain, but not a Chinese clade E (CRF-1) strain. Sera from 3/3 immunized rabbits could neutralize SF162, and from 2/3 neutralized the autologous R2 strain. Dong2003 (variant cross-reactivity, subtype comparisons)

References

Showing 1 of 1 references.

Dong2003 Ming Dong, Peng Fei Zhang, Franziska Grieder, James Lee, Govindaraj Krishnamurthy, Thomas VanCott, Christopher Broder, Victoria R. Polonis, Xiao-Fang Yu, Yiming Shao, Dennis Faix, Patricia Valente, and Gerald V. Quinnan, Jr. Induction of Primary Virus-Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Antibodies in Small Animals by Using an Alphavirus-Derived In Vivo Expression System. J. Virol., 77(5):3119-3130, Mar 2003. PubMed ID: 12584337. Show all entries for this paper.