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Displaying record number 1189

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MAb ID	B4a1
HXB2 Location	Env	Env Epitope Map
Author Location	gp120 (V3)
Research Contact	James Robinson, Tulane University Med School, New Orleans, LA, USA
Epitope
Subtype	B
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Keywords	antibody interactions, co-receptor, variant cross-reactivity

Notes

Showing 2 of 2 notes.

B4a1: The MAb B4e8 binds to the base of the V3 loop, neutralizes multiple primary isolates and was studied for interaction with other MAbs. The anti-V3 MAb B4a1 cross-competes with B4e8. Cavacini2003 (antibody interactions)
B4a1: This study examined antibody interactions, binding and neutralization with a B clade R5 isolate (92US660) and R5X4 isolate (92HT593). Abs generally bound and neutralized the R5X4 isolate better than the R5 isolate. Anti-gp41 MAb F240 binding was not affected by the binding of the V3 loop MAb B4a1, but preincubation with F240 could enhance B4a1 binding of the R5 isolate. B4a1 reacts with many B clade isolates, and preincubation with sCD4 enhances binding to both the R5 and R5X4 isolates. B4a1 increased binding of CD4i MAbs 48d, 17b and A1g8, as well as CD4BS MAbs IgG1b12 and F105 to R5X4 virions, but only A1g8 and IgG1b12 binding was increased by B4a1 to the R5 isolate. Additive effects on neutralization of the R5X4 isolate with B4a1 and CD4i MAbs was observed, presumably due to increased exposure of the CD4i binding site, but not for the R5 isolate. B4a1 had an additive effect on neutralization with 2G12 with the R5X4 virus but not the R5 virus, and did not impact 2F5 neutralization. Cavacini2002 (antibody interactions, co-receptor, variant cross-reactivity)

References

Showing 2 of 2 references.

Cavacini2002 Lisa A. Cavacini, Mark Duval, James Robinson, and Marshall R. Posner. Interactions of Human Antibodies, Epitope Exposure, Antibody Binding and Neutralization of Primary Isolate HIV-1 Virions. AIDS, 16(18):2409-2417, 6 Dec 2002. Erratum in AIDS. 2003 Aug 15;17(12):1863. PubMed ID: 12461414. Show all entries for this paper.

Cavacini2003 Lisa Cavacini, Mark Duval, Leslie Song, Rebecca Sangster, Shi-hua Xiang, Joseph Sodroski, and Marshall Posner. Conformational Changes in env Oligomer Induced by an Antibody Dependent on the V3 Loop Base. AIDS, 17(5):685-689, 28 Mar 2003. PubMed ID: 12646791. Show all entries for this paper.