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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type
Neutralizing
Species (Isotype)	macaque
Patient
Immunogen	SHIV infection
Keywords	variant cross-reactivity

Notes

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Neutralization assays with rsCD4, MAbs, and serum samples from SHIV-infected macaques and HIV-1 infected individuals were used to characterize the antigenic properties of the env glycoprotein of six primary isolate or TCLA SHIV variants. SHIV infected macaques could neutralize autologous virus very effectively, but serum from HXB2c or 89.6 infected animals could not neutralize heterologous SHIVs. Serum from KU infected animals could neutralize only HXB2c, and serum from 89.6PD infected animals could neutralize 89.6, 89.6P, 89.6PD and KB9 (all derived from 89.6) well. Many sera from the SHIV infected macaques could also neutralize HIV-1 strains MN and SF2. Crawford1999 (variant cross-reactivity)

References

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Crawford1999 John M.. Crawford, Patricia L. Earl, Bernard Moss, Kieth A. Reimann, Michael S. Wyand, Kelledy H. Manson, Miroslawa Bilska, Jin Tao Zhou, C. David Pauza, Paul W. H. I. Parren, Dennis R. Burton, Joseph G. Sodroski, Norman L. Letvin, and David C. Montefiori. Characterization of Primary Isolate-Like Variants of Simian-Human Immunodeficiency Virus. J. Virol., 73(12):10199-10207, Dec 1999. PubMed ID: 10559336. Show all entries for this paper.