Search Antibody Database

Found 1 matching record:

Displaying record number 1186

Download this epitope record as JSON.

MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type
Neutralizing
Species (Isotype)	human
Patient
Immunogen	vaccine
Country	Uganda
Keywords	subtype comparisons

Vaccine Details

Vaccine type	canarypox, protein
Vaccine strain	B clade LAI, B clade MN
Vaccine component	Env, Gag, Protease

Notes

Showing 1 of 1 note.

20 Ugandan seronegative individuals were intramuscularly immunized in this study with an ALVAC HIV GagPol and Env vaccine carrying B clade agtigens.3/20 of subjects produced neutralizing antibodies against the autologous HIV-1 clade B strain MN that was T-cell line adapted; 2 also had NAb reactivity against a primary B clade cell line. No NAb cross-reaction was observed with primary viral isolates UG92029 (subtype A) or UG92046 (subtype D). 4/20 had detectable CTL activity against B clade antigen, and one of these cross-reacted with A clade antigen, one with D clade. Cao2003 (subtype comparisons)

References

Showing 1 of 1 reference.

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.