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Displaying record number 1184

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MAb ID	polyclonal
HXB2 Location	Gag	Gag Epitope Map
Author Location	p24
Epitope
Subtype	A
Ab Type
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Country	Uganda
Keywords	subtype comparisons

Vaccine Details

Vaccine type	virus-like particle (VLP)
Vaccine strain	A clade UG5.94UG018
Vaccine component	Gag, gp120

Notes

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BALB/c mice were immunized with VLPs carrying a subtype A gp120. Humoral immune responses directed against B-clade derived Gag (p24) peptides or gp120-Env V3 loop peptide were readily induced following a multi-dose immunization with VLP particles presenting a gp120 molecule from a HIV-1 isolate of clade A. VLP-immunized mice showed autologous and heterologous (against B-clade HIV-1 IIIB strain) neutralization activity. Proliferative responses and CTL were also observed. Buonaguro2002 (subtype comparisons)

References

Showing 1 of 1 reference.

Buonaguro2002 L. Buonaguro, L. Racioppi, M. L. Tornesello, C. Arra, M. L. Visciano, B. Biryahwaho, S. D. K. Sempala, G. Giraldo, and F. M. Buonaguro. Induction of Neutralizing Antibodies and Cytotoxic T Lymphocytes in Balb/c Mice Immunized with Virus-Like Particles Presenting a gp120 Molecule from a HIV-1 Isolate of Clade A. Antiviral Res., 54(3):189-201, Jun 2002. PubMed ID: 12062391. Show all entries for this paper.