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Displaying record number 1178

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MAb ID	polyclonal
HXB2 Location	Tat(1-20 + 1-20) DNA(5831..5890,5831..5890)	Tat Epitope Map
Author Location	Tat(1-20 IIIB BH10)
Epitope	MEPVDPRLEPWKHPGSQPKT?	Epitope Alignment
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	mouse(IgA, IgG)
Patient
Immunogen	vaccine
Keywords	adjuvant comparison, genital and mucosal immunity, immunodominance, Th1, Th2, vaccine-induced immune responses

Vaccine Details

Notes

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• Intranasal immunization of BALB/c mice Tat with MALP-2 induced stronger immune responses than i.p. vaccination of Tat with IFA. Also i.n. MALP-2 vaccination favored Th1 responses, while i.p IFA favored Th2. Ab, T help and CTL responses were observed. MALP-2 enhanced Tat-specific IgA responses in the lung and in the genital tract. Three linear Ab epitopes were recognized. The most frequent response (80% of vaginal lavage, 100% of sera and lung lavage) was to Tat peptide 1-20. The second strongest to Tat 46-60 (20% of vaginal lavage, 50% of lung lavage, 50% of sera). Finally, 50% of the sera of Tat+ IFA i.p. immunized mice recognized Tat 73-86. Borsutzky2003 (adjuvant comparison, genital and mucosal immunity, vaccine-induced immune responses, immunodominance, Th1, Th2)

References

Showing 1 of 1 reference.

Borsutzky2003 Stefan Borsutzky, Valeria Fiorelli, Thomas Ebensen, Antonella Tripiciano, Faiza Rharbaoui, Arianna Scoglio, Claudia Link, Filomena Nappi, Michael Morr, Stefano Buttó, Aurelio Cafaro, Peter F. Mühlradt, Barbara Ensoli, and Carlos A. Guzmán. Efficient Mucosal Delivery of the HIV-1 Tat Protein using the Synthetic Lipopeptide MALP-2 as Adjuvant. Eur. J. Immunol., 33(6):1548-1556, Jun 2003. PubMed ID: 12778472. Show all entries for this paper.