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Displaying record number 1123

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MAb ID	polyclonal
HXB2 Location	gp160(310-318) DNA(7152..7178)	gp160 Epitope Map
Author Location	gp120(gp120 )
Epitope	`QRGPGRAFV?`	Epitope Alignment
Ab Type
Neutralizing	L
Species (Isotype)	mouse(IgA, IgG1, IgG2a)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide keyhole limpet hemocyanin (KLH) conjugate, peptide Brucella abortus (Ba) conjugate, peptide lipopolysaccharide (LPS) conjugate
Vaccine strain	B clade MN
Vaccine component	Env V3

Notes

Showing 1 of 1 note.

Internasal (i.n.) immunization with V3-Ba induced mucosal anti-V3 NAbs and IFN-gamma secreting T cells -- V3-Ba, V3-KLH and V3-LPS could each induce serum and mucosal IgA and IgG in BALB/c mice -- i.n. plus i.p. immunizations gave higher titers than i.n. alone -- the response to V3-KLH was mainly restricted to IgG1, and to V3-Ba, IgG2a -- class II KO mice (CD4+-deficient) did not respond to V3-KLH, but did respond to V3-Ba, suggesting that V3-Ba may be effective in eliciting Ab responses in HIV-1 infected individuals that have impaired CD4+ T cell function. Database note: First author "GoldingB" is also found as "Golding" on annotated papers in this database, but is distinct from "GoldingH." GoldingB2002

References

Showing 1 of 1 reference.

GoldingB2002 Basil Golding, Nancy Eller, Lily Levy, Paul Beining, John Inman, Natasha Matthews, Dorothy E. Scott, and Hana Golding. Mucosal Immunity in Mice Immunized with HIV-1 Peptide Conjugated to Brucella abortus. Vaccine, 20(9-10):1445-1450, 31 Jan 2002. PubMed ID: 11818165. Show all entries for this paper.