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MAb ID	polyclonal
HXB2 Location	HIV-1	HIV-1 Epitope Map
Author Location	HIV-1
Epitope
Ab Type
Neutralizing
Species (Isotype)	human(IgE)
Patient
Immunogen	HIV-1 infection
Keywords

Notes

Showing 2 of 2 notes.

Pediatric long term survivors (LTS) have been found to carry HIV-1 specific IgE -- serum from these children inhibit HIV-1 production in culture, but this inhibition did not seem to be due to neutralization, rather due to a cytoxic event -- serum lost the HIV-1 inhibitory effect when depleted of IgE. Pellegrino2002
HIV-specific IgE found in clinically healthy HIV-1 infected children. Secord1996

References

Showing 2 of 2 references.

Secord1996 E. A. Secord, G. I. Kleiner, D. L. Auci, T. Smith-Norowitz, S. Chice, A. Finkielstein, M. Nowakowski, S. Fikrig, and H. G. Durkin. IgE against HIV Proteins in Clinically Healthy Children with HIV Disease. J Allergy Clin Immunol, 98(5 Pt 1):979-984, Nov 1996. PubMed ID: 8939162. Show all entries for this paper.

Pellegrino2002 Michael G. Pellegrino, Martin H. Bluth, Tamar Smith-Norowitz, Senih Fikrig, David J. Volsky, Hamid Moallem, Dominick L. Auci, Maja Nowakowski, and Helen G. Durkin. HIV Type 1-Specific IgE in Serum of Long-Term Surviving Children Inhibits HIV Type 1 Production in Vitro. AIDS Res. Hum. Retroviruses, 18(5):363-372, 20 Mar 2002. PubMed ID: 11897038. Show all entries for this paper.