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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type
Neutralizing	P
Species (Isotype)	human(IgA)
Patient
Immunogen	HIV-1 exposed seronegative
Keywords

Notes

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IgA from the genital tract, saliva and plasma from highly exposed persistently seronegative (HEPS) individuals can inhibit transcytosis of HIV-1 across a transwall system that provides a tight epithelial cell layer---50% of the IgA samples studied were able to inhibit transcytosis of at least one of two primary isolates tested, indicating this may be an important mechanism against sexual acquisition of HIV-1. Devito2000b

References

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Devito2000b Claudia Devito, Kristina Broliden, Rupert Kaul, Lennart Svensson, Kari Johansen, Peter Kiama, Joshua Kimani, Lucia Lopalco, Stephanie Piconi, Job J. Bwayo, Fancis Plummer, Maria Clerici, and Jorma Hinkula. Mucosal and Plasma IgA from HIV-1-Exposed Uninfected Individuals Inhibit HIV-1 Transcytosis Across Human Epithelial Cells. J. Immunol., 165(9):5170-5176, 1 Nov 2000. PubMed ID: 11046049. Show all entries for this paper.