Search Antibody Database

Found 1 matching record:

Displaying record number 1080

Download this epitope record as JSON.

MAb ID	polyclonal
HXB2 Location	Gag	Gag Epitope Map
Author Location
Epitope
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1, IgG2a)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	DNA with CMV promotor, DNA with CMV/MCK hybrid promotor, DNA with MCK promotor

Notes

Showing 1 of 1 note.

The ability of three different promoters to induce Gag specific immune responses was compared. The cytomegaliovirus (CMV) early gene promoter, which allows constitutive expression in different cells of host tissue, the tissue specific muscle creatine kinase (MCK) promoter, which may be restricted to differentiated, multinucleated myofibers and so safer, and a hybrid MCK/CMV promoter -- intramuscular immunization of BALB/c mice utilizing the MCK promoter in combination with a codon optimized gag gene generated humoral (IgG1 (Th1) and IgG2a (Th2)) and CTL immune responses against HIV-1 Gag, however, the quantified immune parameters were clearly reduced as compared to CMV promotor-driven Gag expression. Bojak2002

References

Showing 1 of 1 reference.

Bojak2002 Alexandra Bojak, Diana Hammer, Hans Wolf, and Ralf Wagner. Muscle Specific Versus Ubiquitous Expression of Gag Based HIV-1 DNA Vaccines: A Comparative Analysis. Vaccine, 20(15):1975-1979, 6 May 2002. PubMed ID: 11983257. Show all entries for this paper.