Search Antibody Database

Found 1 matching record:

Displaying record number 1045

Download this epitope record as JSON.

MAb ID	6.7 (Xeno-mAb 6.7)
HXB2 Location	Env	Env Epitope Map
Author Location	gp120(gp120 SF162)
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope
Subtype	B
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

6.7: This review provides summaries of Abs that bind to HIV-1 Env. There are many V3 MAbs, many neutralize some TCLA strains, and a subset can also neutralize some primary isolates. 6.7 was non-neutralizing. Gorny2003 (review)
6.7: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- 3/4 V3 MAbs bound a similar linear epitope between positions 11-30 of the MN V3 loop (8E11/A8, 6.1, and 6.7), but only 8E11/A8 could weakly neutralize autologous strain SF162. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.