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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	human(IgG)
Patient
Immunogen	HIV-1 infection
Keywords

Notes

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Random peptide libraries were screened using sera from HIV-infected subjects to identify mimotopes, peptides that mimic conformational or linear epitopes specifically recognized by Abs from HIV-1 infected individuals -- the sera of simian SHIV-infected monkeys also recognized the specific peptides, and mice immunized with the selected peptides elicited HIV-specific Abs that neutralized HIV-1 isolates IIIB and NL4-3. Scala1999

References

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Scala1999 Giuseppe Scala, Xueni Chen, Waimin Liu, Jean Noel Telles, Oren J. Cohen, Mauro Vaccarezza, Tatsu Igarashi, and Anthony S. Fauci. Selection of HIV-Specific Immunogenic Epitopes by Screening Random Peptide Libraries with HIV-1-Positive Sera. J. Immunol., 162(10):6155-6161, 15 May 1999. PubMed ID: 10229859. Show all entries for this paper.