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MAb ID	polyclonal
HXB2 Location	gp160(304-322) DNA(7134..7190)	gp160 Epitope Map
Author Location	(gp120 MN)
Epitope	RKRIHIGPGRAFYTTKN	Epitope Alignment
Subtype	multiple
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Keywords

Notes

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• The Ab response of 829 HIV-1 infected subjects from eight geographic areas to a set of different V3 peptides was determined by ELISA and cross-inhibition studies -- the Ab binding pattern was highly variable, depended on the geographic origin of the sample -- 297 sera were tested in a neutralization assay -- there was a correlation between Ab binding to the MN V3 loop and MN neutralizing titer, but with neutralization of IIIB or CBL-4. CheingsongPopov1992

References

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CheingsongPopov1992 R. Cheingsong-Popov, D. Callow, S. Beddows, S. Shaunak, C. Wasi, P. Kaleebu, C. Gilks, I. V. Petrascu, M. M. Garaev, and D. M. Watts. Geographic Diversity of Human Immunodeficiency Virus Type 1: Serologic Reactivity to Env Epitopes and Relationship to Neutralization. J. Infect. Dis., 165(2):256-261, Feb 1992. PubMed ID: 1370525. Show all entries for this paper.