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MAb ID	polyclonal
HXB2 Location	gp160(302-317) DNA(7128..7175)	gp160 Epitope Map
Author Location	Env( B consensus)
Epitope	NTRKSIHIGPGRAF	Epitope Alignment
Subtype	B
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Keywords

Notes

Showing 2 of 2 notes.

• Similarity level of the polyclonal Ab binding site pentapeptide IGPGR to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 0 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
• Ab responses before HAART therapy and after one year of therapy were measured in 8 individuals that were classified HAART successes, and 10 patients who were classified as HAART failures -- V3 peptide antibody binding titers to the B-consensus and MN and SF2 variants, and neutralization of HIV-1 MN and four subtype B clinical isolates were tested -- subjects with strong anti-V3 and NAb humoral immune responses before starting HAART were more likely to achieve sustained viral suppression to <500 copies RNA/ml on HAART -- HIV-specific Ab responses declined after 1 year of successful viral suppression on HAART. Morris2001

References

Showing 2 of 2 references.

Morris2001 Mary Kate Morris, David A. Katzenstein, Dennis Israelski, Andrew Zolopa, R. Michael Hendry, and Carl V. Hanson. Characterization of the HIV-1 Specific Humoral Immune Response During Highly Active Antiretroviral Therapy (HAART). J. Acquir. Immune Defic. Syndr., 28(5):405-415, 15 Dec 2001. PubMed ID: 11744827. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.