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Displaying record number 1002

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MAb ID	55/68b
HXB2 Location	Env	Env Epitope Map
Author Location	gp120(300-315)
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)
Patient
Immunogen
Keywords

Notes

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55/68b: The most variable amino acids in the V3 loop were replaced with serines to make the immunodominant V3 loop less immunogenic -- these changes did not affect the ability of sCD4 or MAbs to V1/V2, C1 and C4 to bind, and anti-V3 MAb 55/68b binding was abrogated by V3 serine substitutions in the V3 loop -- mice injected with serine substituted gp120 had a reduced response relative to wildtype, and no enhanced immunogenicity of conserved regions. Peet1998

References

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Peet1998 N. M. Peet, J. A. McKeating, J. B. de Souza, I. M. Roitt, P. J. Delves, and T. Lund. The Effect of Low-Profile Serine Substitutions in the V3 Loop of HIV-1. Virology, 251:59-70, 1998. PubMed ID: 9813203. Show all entries for this paper.