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MAb ID 3E11
HXB2 Location Gag(19-38)
Gag Epitope Map
Author Location p17(19-38 SIVmac)
Epitope IRLPGGKKKYMLKHVVWAA Epitope Alignment
Ab Type  
Species (Isotype) mouse(IgG1)
Immunogen vaccine

Vaccine Details

Vaccine type inactivated HIV
Vaccine strain B clade AGM TYO-7
Vaccine component HIV-1


Showing 2 of 2 notes.


Showing 2 of 2 references.

Otteken1992 A. Otteken, S. Nick, W. Bergter, G. Voss, A.C. Faisst, C. Stahl-Hennig, and G. Hunsmann. Identification of a gag protein epitope conserved among all four groups of primate immunodeficiency viruses by using monoclonal antibodies. J. Gen. Virol., 73:2721-2724, 1992. Anti-SIVagmTYO-7 Mabs were obtained by intraperitoneal immunization of mice. Two reacted with p17 and three with p24. The anti-p24 MAbs recognized an epitope present in SIVagmTYO-7, SIVagmTYO-5, and HIV-2/SIVmac. The anti-p17 recognized an epitope present in SIVagmTYO-7, SIVagmTYO-5, HIV-2/SIVmac, SIVagmTYO-1, HIV-1, and SIVmnd. This study shows that the matrix protein expresses at least one highly conserved epitope. PubMed ID: 1383399. Show all entries for this paper.

Nilsen1996 B. M. Nilsen, I. R. Haugan, K. Berg, L. Olsen, P. O. Brown, and D. E. Helland. Monoclonal Antibodies against Human Immunodeficiency Virus Type 1 Integrase: Epitope Mapping and Differential Effects of Integrase Activities In Vitro. J. Virol., 70:1580-1587, 1996. In this study, 17 anti-integrase murine Mabs were generated and epitopes were mapped by deletion mutations and peptide scanning. The ability of MAb binding to inhibit (or stimulate) end-processing, DNA joining, reintegration, and disintegration enzyme functions it in vitro was determined. PubMed ID: 8627677. Show all entries for this paper.

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