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MAb ID	3E11
HXB2 Location	Gag(19-38) DNA(844..903)	Gag Epitope Map
Author Location	p17(19-38 SIVmac)
Epitope	`IRLPGGKKKYMLKHVVWAA`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade AGM TYO-7
Vaccine component	HIV-1

Notes

Showing 2 of 2 notes.

3E11: Recognized an epitope present on HIV-2/SIVmac (MAC251/32H), SIVagm, HIV-1, and SIVmnd, demonstrating that the matrix protein of all nine HIV and SIV isolates tested in this study expresses at least one highly conserved immunogenic epitope. Otteken1992
3E11: There is another MAb with this ID that recognizes integrase. Nilsen1996

References

Showing 2 of 2 references.

Otteken1992 A. Otteken, S. Nick, W. Bergter, G. Voss, A.C. Faisst, C. Stahl-Hennig, and G. Hunsmann. Identification of a gag protein epitope conserved among all four groups of primate immunodeficiency viruses by using monoclonal antibodies. J. Gen. Virol., 73:2721-2724, 1992. Anti-SIVagmTYO-7 Mabs were obtained by intraperitoneal immunization of mice. Two reacted with p17 and three with p24. The anti-p24 MAbs recognized an epitope present in SIVagmTYO-7, SIVagmTYO-5, and HIV-2/SIVmac. The anti-p17 recognized an epitope present in SIVagmTYO-7, SIVagmTYO-5, HIV-2/SIVmac, SIVagmTYO-1, HIV-1, and SIVmnd. This study shows that the matrix protein expresses at least one highly conserved epitope. PubMed ID: 1383399. Show all entries for this paper.

Nilsen1996 B. M. Nilsen, I. R. Haugan, K. Berg, L. Olsen, P. O. Brown, and D. E. Helland. Monoclonal Antibodies against Human Immunodeficiency Virus Type 1 Integrase: Epitope Mapping and Differential Effects of Integrase Activities In Vitro. J. Virol., 70:1580-1587, 1996. In this study, 17 anti-integrase murine Mabs were generated and epitopes were mapped by deletion mutations and peptide scanning. The ability of MAb binding to inhibit (or stimulate) end-processing, DNA joining, reintegration, and disintegration enzyme functions it in vitro was determined. PubMed ID: 8627677. Show all entries for this paper.