Purpose:
to provide HIV-1 Env coordinates of contacts and other sites associated with neutralizing antibodies. Some of these data are also summarized in a spreadsheet (.xlsx). For details, see Help.
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Env Feature ID | Title | Antibody class | Reference | Site type | Experimental method | MAb name | |
---|---|---|---|---|---|---|---|
Details | 12 | Mutation affects PGV04, b12, VRC01, CD4-IgG neutralization | CD4BS | Falkowska2012 | neutralization | neutralization assay | b12 VRC01 VRC-PG04 |
Details | 14 | b12 contacts | CD4BS | Zhou2007 | contacts | X-ray crystallography | b12 |
Details | 37 | b12 signature predictions | CD4BS | West2013 | signature | computational prediction | b12 |
Details | 102 | b12 signature sites | CD4BS | Gnanakaran2010 | signature | computational prediction | b12 |
Details | 123 | Mutation decreases binding to CD4BS mAbs | CD4BS | Easterhoff2017 | binding | binding assay | b12 b6 CH13 CH28 CH98 HJ16 VRC01 VRC-PG04 |
Details | 203 | Signature Analysis Summary | CD4BS | Bricault2019 | signature | computational prediction | b12 |
Details | 426 | Mutation increases neutralization sensitivity | CD4BS | Leaman2013 | neutralization | neutralization assay, other | b12 b6 |
Details | 472 | Mutation affects neutralization of b12 | CD4BS | ORourke2012 | neutralization | neutralization assay | b12 |
Details | 518 | mutation increases sensitivity to b12 | CD4BS | Blish2008 | neutralization | neutralization assay | b12 |
Details | 521 | mutation increases sensitivity to b12 | CD4BS | Ringe2012a | neutralization | neutralization assay | b12 |
Details | 533 | b12 binding alanine scanning | CD4BS | Pantophlet2003 | binding | alanine scanning, binding assay | b12 |