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HIV Sequence Database



Env Feature Database

Neutralizing Antibody Contacts & Features

Purpose: to provide HIV-1 Env coordinates of contacts and other sites associated with neutralizing antibodies. Some of these data are also summarized in a spreadsheet (.xlsx). For details, see Help.
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Found 19 record(s).

Env Feature IDTitleAntibody classReferenceSite typeExperimental methodMAb name
Details8VRC01 contactsCD4BSWu2011 Zhou2010 contactsVRC01
Details12Mutation affects PGV04, b12, VRC01, CD4-IgG neutralizationCD4BSFalkowska2012 neutralizationneutralization assayb12 VRC01 VRC-PG04
Details44VRC01 signature predictionsCD4BSWest2013 signaturecomputational predictionVRC01
Details63VRC01 residue predictionCD4BSChuang2013 Chuang2014 signatureVRC01
Details73Sequence changes after immunotherapy with VRC01CD4BSLynch2015 immunotherapysequence analysisVRC01
Details84Electrostatic interactions with D368CD4BSBonsignori2016 bindingCH235.12 CH235.9 VRC01
Details116mutations affecting VRC01 bindingCD4BSDingens2019 Huang2016a bindingalanine scanning, binding assay, mutational analysisVRC01
Details123Mutation decreases binding to CD4BS mAbsCD4BSEasterhoff2017 bindingbinding assayb12 b6 CH13 CH28 CH98 HJ16 VRC01 VRC-PG04
Details167Removal of glycosylation sites confers binding to germline-reverted NIH45-46 and VRC01CD4BSMcGuire2013 McGuire2016 bindingVRC01
Details200hypervariable loop characteristic correlations with bNAb sensitivityCD4BSBricault2019 signaturecomputational prediction12A12 3BNC117 8ANC131 CH103 CH235.12 N6 NIH45-46 VRC01 VRC07 VRC07-523-LS
Details209Signature Analysis SummaryCD4BSBricault2019 signaturecomputational predictionVRC01
Details246Neutralization of Env 426c and its glycan-deleted mutant by CD4BS AbsCD4BSLaBranche2018 neutralizationneutralization assay12A12 3BNC117 VRC01 VRC03 VRC07 VRC18b VRC-PG20
Details282Mutation affects VRC01 neutralizationCD4BSDingens2019 Kong2016a Schommers2020 neutralizationneutralization assayVRC01
Details294Mutations associated with immunotherapy with BG24 or VRC01CD4BSBarnes2022 immunotherapysequence analysisBG24 VRC01
Details295Mutation abrogates BG24 OR VRC01 neutralizationCD4BSBarnes2022 neutralizationneutralization assayBG24 VRC01
Details336VRC01 contactsCD4BSDingens2019 contactsmolecular modelingVRC01
Details396mutations affecting VRC01 bindingCD4BSKwon2015 bindingbinding assay, mutational analysisVRC01
Details475Mutation affects neutralization of VRC01CD4BSORourke2012 neutralizationneutralization assayVRC01
Details489Disulfide bond introduced in V1V2 affects binding of VRC01CD4BSdeTaeye2019 bindingbinding assay, mutational analysisVRC01



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last modified: Tue Nov 7 17:32 2023


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